I am interested in how parasites and pathogens drive rapid evolution in their hosts, and the consequences of this for the evolution of genomes, survival of populations and pathogen dynamics.
Research Area
Our research explores the genetic and evolutionary dynamics that govern interactions between hosts and their parasites. The group investigates the molecular basis of natural variation in infection susceptibility and the evolutionary processes that maintain this diversity within populations. Through an integrative approach combining genomics, evolutionary theory, and experimental biology, we aim to advances understanding of how genetic diversity in host defence evolves, informing broader questions in evolutionary biology, epidemiology, and vector-borne disease control.
Working primarily with Drosophila, Aedes aegypti, and rabbit models, we employ genome-wide association analyses, population genomics, and experimental evolution to dissect how natural selection shapes host–pathogen coevolution. Our studies have studies revealed how immune system genes evolve under fluctuating selective pressures and how resistance to infection can impose evolutionary trade-offs.
The laboratory also examines the genetic determinants of vector competence in mosquitoes, elucidating how host factors influence pathogen transmission. Recent work has provided insights into adaptive responses of wild rabbit populations to myxoma virus epidemics, highlighting the rapid pace of host evolutionary change in the face of emerging pathogens.
Project Interests
I am interested in developing projects in three model systems—rabbits, mosquitoes, and Drosophila—to investigate the evolution of host–parasite interactions. In mosquitoes, we aim to understand the population dynamics of Wolbachia infections used in public health programs to suppress dengue transmission, informing improved release strategies. In rabbits, we will analyse genomic data from historical and modern samples to reveal how immune systems evolved through viral pandemics. In Drosophila, long-term experimental populations will dissect the genetic basis of adaptation to parasites. Projects may range from experimental evolution to computational genomics, depending on the student’s interests and expertise.